Development of Oncotarget and the New Sections

Oncortarget is a traditional journal with free access. The oncotarget publishes online papers in weekly issues. Each paper is printed on special demand. The mission at oncotarget is to make scientific results by maximizing the impact of research through insightful review. They allow discoveries to be shared quickly by eliminating border between specialties. They link different fields of biomedical science. Through the leadership of prominent scientists, the journal enables researchers to contribute to the progress of science. Their ultimate goal is to ensure life without diseases. The privately held company that employees about 50 employees has experienced success and is now prompted to launch sections beyond oncology. Several articles has been edited in oncotarget.

One of the eye-catching articles is for cellular rejuvenation. In the article, the author identified that dietary energy intake is acceptable as a powerful and robust intervention to extend lifespan and slow down aging. One of the suitable indicator of lifespan extension according to oncotarget is inhibition of mTOR activity. The mechanism Target of Rapamycin or the mTOR is promoting growth that is activated by circulating insulin and amino acids and other factors that drive the synthesis and growth of cellular proteins. mTOR is used due to its ability to counteract cellular cleansing and rejuvenation by preventing autophagy and promoting derangement of metabolic. Mutant models with defective mTOR activity are no longer responsive to lifespan extension by DR. mTOR hyperactivation is constantly triggered hence circulating nutrients to cellular senescence and aging. Follow Oncotarget on Twitter.

Under the leadership of Michael Lisanti who is the former editor in chief of the American Journal of Pathology, oncotarget has launched a pathology section. The organization which was formed in May 2010 has received an impact factor of 6.63 in two years in a row. Its popularity and success have led to the launch of new sections, pathology being one of them.

Oncotarget sponsored the Gordon Research Conference held at the University of England. Howard and Rama chaired the conference. Its main aim was discussing rediscovering metalloproteinases as disease targets. Since the discovery of tissue as a remodeling enzyme, matrix MMPs and other related ADAM and ADAMTS families have been named the highest contributor of diseases in human beings. The conference discussed these contributors and the clinical trials that have been performed. Visit his profile on Google Scholar.

Timothy Armour and his Leadership Skills

Timothy Armour serves as the Chairman and also the Chief Executive Officer at Capital Group. Timothy wrote a commentary about Warren Buffet being wrong about the investment strategy. According to Tim, Warren has wagered approximately $1 million for charity to get better investment returns compared to hedge fund managers’ group by investing in a passive index fund of S&P 500. Just like Warren Buffet, Timothy Armour agrees that many expensive and mediocre funds usually shortchange investors. Timothy says that he supported Warren’s commitment to simple and low-cost investments to be bought and held for a long term and more information click here.

Timothy Armour says that the bottom-up investing approach by Warren Buffer has managed to prove itself for many years. This includes analyzing companies rigorously and creating a strong portfolio. He also agrees that there is a need for Americans to save more when it comes to retirement, to invest and also stay invested. According to Timothy Armour, it is time for people to challenge the idea that better retirement is brought about by passive index returns. He adds that it is not about passive or active index returns but delivering good investment returns that are long term.

Commonly referred to like Tim, Timothy Armour is the Principal Executive Officer at the Capital Research and Management Company. Tim has a broad experience in the investment industry and has acquired a reputation as a reliable and efficient investment advisor. He offers his advice about the right investments to new and established investors to get good investment returns. He formerly worked as an Equity Investment Analyst at the Capital Group where he was responsible for handling global telecommunications. In 1983, Timothy Armour joined Capital Group Companies, Inc and had over the years held different positions at the company. His hard work and commitment have seen him through one promotion to another. He started his career when he participated in The Associates Program and learn more about Timothy.

Timothy Armour graduated from the Middlebury College with a bachelor’s Degree in Economics. He attributes his success to hard work, discipline, and passion. Through his leadership, Capital Group has registered massive success and expansion and Timothy’s lacrosse camp.

More visit: https://www.thecapitalgroup.com/us/about.html

Kate Hudson’s Fabletics Could Catch Amazon

If you were to say that a few years ago a new apparel company could topple Amazon from the top spot, no one would really give you a second thought. Amazon is in competition with thousand of other apparel companies in a very competitive niche, but they bring in 20 percent of all sales year after year. Today there appears to be one high-quality active-wear company that is poised to catch and pass Amazon, and Kate Hudson’s Fabletics is not just a one-hit wonder, they have sold $250 million in sales in the same space as Amazon over three years.

 

Hudson speaks about her athleisure brand in a different way than you might suspect, crediting the success to the membership package combined with the sales process known as reverse showrooming. Lets look at how this translates in the real world, as we first need to head over to the Fabletics stores in the local mall. Women shop here much differently than they do at the other clothing stores. Here they try on all the clothing they like with no sales pressure, they take the Fabletics Lifestyle Quiz, and they are free to window shop all they like. This relaxed atmosphere connects with these customers in a very specific way.

 

The real numbers don’t begin to show until these same customers decide they want to shop at the e-commerce store. Now when these women go to the Fabletics website, all the merchandise that fit in the store is now sitting waiting for them online. Now online the inventory is much bigger, so since they already know what sizes fit, these customers start picking pieces of active-wear that they like based on colors, styles, and even the latest arrivals to the store. With no concern if the merchandise will fit, the buyers grab more pieces of high-quality workout apparel than they would have at sites like eBay or Amazon where size concerns slow down the sales process.

 

Kate Hudson’s Fabletics is about to change the way women shop, and knowing they have busy schedules and concerns about how apparel fits, this formula seems to be the perfect solution. These women can shop once in the Fabletics retail store and then return online over and over to just keep buying. Membership also rewards these women with free online shipping, discounts on active-wear, and even a personal assistant who selects a piece of apparel each month for these women based on quiz answers.

Mechanisms Mike Heiligenstein Is Using To Reduce Traffic Congestion

Mike Heiligenstein was quick to point out that Austin was in need of the Central Texas Regional Mobility Authority services as soon as the American-Statesman had an issue with the congestion of roads. Heiligenstein, the executive director of Central Texas Regional Mobility Authority, pointed out some of the work that the firm has done to ensure that it deals with the issue of congestion on roads was building highways and Toll roads. For instance, in 183 A, the firm made a Toll Road in Ceder Park and Leander and this has transformed the communities in this area as they have experienced tremendous growth. The firm has also constricted the U.S. 290 Toll road that is between Austin and Manor which has helped in tripling the capacity compare do the previous road, and it also has improved the non-toll lanes.Learn more : http://www.bizjournals.com/sanantonio/print-edition/2014/01/10/fifteen-minutes-with-mike.html

 

Heiligenstein states that the Mobility Authority is not all about making roads, but also keeping up with the latest trends. The firm is planning on building a MoPac Express Lanes which will help to institute variable tolling and use sophisticated technology to help with the traffic flow. The use of MoPac will help in synchronizing the supply and demand and make sure that the traffic is predictable. The fiber line will be constructed between 183 South projects and the 290 airport road. The construction will be put in place waiting for the say to improve the current road infrastructure. The firm has partnered with Metropia and created a mobile traffic app that is integrated with the traffic monitoring system as a way of giving alternatives to commuters. The firm also believes that carpooling would help deal with traffic and this is the reason it has partnered with Carma to build carpooling app.Learn more : http://www.slideshare.net/mikeheiligenstein/mike-heiligenstein-of-the-ctrma-the-central-texas-approach

 

Mike Heiligenstein has been working with the mobile authority since 2003 learn more : http://www.bizjournals.com/sanantonio/print-edition/2014/01/10/fifteen-minutes-with-mike.html. He has seen the business thriving from a startup company to a firm that is nationally recognized. Heiligenstein is all about making sure that there is no congestion on the road. It is this reason that makes him advocate for the use of bicycle and the facilities of pedestrians and has strived to offer this service when possible. Heiligenstein has been working in the public office for some time; he was a Round Rock City, Williamson County Commissioner, and in charge of numerous infrastructure projects like parkland acquisition, transport projects, and the development of Brushy Creek Regional Trail. Heiligenstein was a founding board member and twice the vice chair of Austin-San Antonio Corridor Council.Learn more : http://www.dot.state.tx.us/ttf2009/People/MikeHeiligenstein.htm

 

 

Adam Goldenberg: Bringing a New Era in the Fashion Industry

Adam Goldenberg is the co-founder of JustFab Inc. in 2010 together with Don Ressler. The company is an online subscription outlet that sells selections of fashion shoes, jewelry, handbags, and denim. The company provides an individualized shopping experience based on subscribers’ fashion preferences. JustFab (changed name to TechStyle) has reshaped the fashion e-commerce experience.

The duo knows how to start and grow businesses, spot trends and develop industry-leading brands that cannot be outmatched easily. Their success is based on the combination of doing the business with fun and passion in an industry which people don’t take seriously. Due to these qualities, JustFab has become the trend-setter in fashion e-commerce on vator.tv.

They started the company to remove the status quo in the fashion industry by integrating technology and the whole fashion business cycle, starting from designing, manufacturing, product distribution and mainly customer experience. JustFab Inc. is the parent company to other fashion brands such as ShoeDazzle, Fabletics, Fabkids, and FL2.

Subscription into JustFab products is at $39.95 per month and is automatically given upon buying. Members are required to complete a survey about their fashion preferences on styleforum.net. Each month, a stylist chooses items based on the preferences and members are given an opportunity to choose from these selections or request new choices. If the members choose to skip the month, no charge is accrued.

Since his youth, Adam Goldenberg has been a successful entrepreneur. At the age of 13, he started his online bulletin board which later grew into a gaming website known as Gamers’ Alliance. At the age of 17, Gamers’ Alliance was bought by Intermix which later named him as the company’s COO at the age of 19.

Adam Goldenberg and Don Ressler are also the co-founders of the beauty company, Intelligent Beauty in 2006. The company is an e-commerce internet brand incubator operating businesses in beauty, personal care, and fashion. The company’s headquarters are in El Segundo California.

Another of Adam Goldenberg’s and Don Ressler’s main investments is Fabletics. This is an online retailer for athletic wear was founded in 2013 at http://rgtadvisors.com/bio/adam-goldenberg/. Part of the TechStyle Company, this is the fasted growing label as of 2015. As of 2016, April, Fabletics had six mortar and brick locations and had plans to open 75-100 new outlets for the next five years.

Viable Lessons from Samuel Strauch

Samuel Strauch is an investor in real estates. He began his investment in real estates in 2002 when he established. Metrik Real Estates Company. The company is based in South Florida. For more than one decade, he has steered the company to greater heights in the market through provision of a leadership role, financing, and management. The skills acquired have greatly influenced the outcomes in increasing profits earned and opening international markets for the company.

Educational background

Samuel Strauch perused different degree programs in real estate and international marketing which have been useful in managing the company. Between 1991 and 1994, he attended Hofstra University where he perused business. He completed his studies at Harvard University and Erasmus University Rotterdam. The skills have been essential especially in meeting foreign investors who they have joined hands in transforming the city through real estate investment.

Here are some lessons to borrow from Samuels’s investment journey:

  • Being curious: the ability to see new opportunities and have the desire to explore and learn more are very useful. Samuel Strauch says that he is very curious about learning new opportunities in the real estate market and trying to figure ways on how he can capitalize on available opportunities. It is bets to choose wise investments and evaluate them thoroughly so that risks involved are reduced.

 

  • Keeping an eye on current trends: Samuel speaks about the current generation and the rate at which things are changing. It is phenomenon to see how many transformations are happening in the society and property markets as a whole. Staying updated on these changes is essential in meeting customer demands and designing properties that suit their preferences. For you to benefit and stay on top of your business, it is best that you stay updated on what customers are searching for and contact him.

 

  • Making wise decisions in recruiting your staff: a business entity should totally be independent of your personal life. When employing your employees, you must put skills and qualifications of a person ahead of your friendship. Do not hire a person because he or she is your friend because this could affect the performance of your business. The same case happened to him forcing him to recruit new staff members and Samuel’s lacrosse camp.

More visit: https://soundcloud.com/samuel-strauch